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Creamy Cajun chicken pasta with penne, bell peppers, and parsley served in a bowl.

Creamy Cajun Chicken Pasta

This cozy skillet pasta is rich, gently spicy, and perfect for turning an ordinary night into something special.
5 from 1 vote
Prep Time 10 minutes
Cook Time 15 minutes
Simmer Time 5 minutes
Total Time 30 minutes
Servings: 4
Calories: 640kcal
Course: dinner, Main Course
Cuisine: American, Cajun-Inspired
Keyword: Cajun Chicken, cajun chicken pasta, chicken skillet pasta, Creamy Cajun Chicken Pasta, creamy pasta, weeknight dinner
Cost: $16

🛒 Ingredients

  • 12 oz penne pasta dry tube-shaped pasta
  • 3 teaspoons Cajun seasoning store-bought spice blend
  • ½ teaspoon salt fine sea salt divided
  • ½ teaspoon black pepper freshly ground divided
  • 1 ½ lb boneless skinless chicken breast cut into bite-size chunks
  • 3 tablespoons salted butter divided for sautéing
  • ½ yellow onion finely diced
  • 2 bell peppers thinly sliced any color
  • 1 ½ cups heavy cream full-fat for best texture
  • ¾ teaspoon smoked paprika for subtle smokiness
  • ½ teaspoon dried basil crumbled between fingers
  • ¼ teaspoon garlic powder fine and dry
  • ½ cup Parmesan cheese freshly grated not pre-shredded

📋 Instructions

  • Bring a pot of salted water to a boil and cook the pasta until just al dente, then drain and set aside.
  • Combine most of the Cajun seasoning with half the salt and half the pepper in a bowl, add the chicken, and toss until every piece is well coated.
  • Melt two tablespoons of butter in a large skillet over medium heat until bubbling gently.
  • Add the chicken in a single layer and cook, turning occasionally, until golden on the outside and cooked through, then transfer to a plate.
  • Add the remaining butter to the same pan and let it melt completely.
  • Stir in the sliced peppers and diced onion and cook until they begin to soften but still hold some shape.
  • Pour in the cream, then add the remaining Cajun seasoning, salt, pepper, smoked paprika, basil, and garlic powder, and bring the sauce to a gentle boil.
  • Lower the heat and let the sauce simmer until slightly thickened and silky.
  • Return the chicken to the skillet, add the cooked pasta and Parmesan, and toss until everything is coated and the cheese has melted into the sauce.
  • Serve hot and enjoy right away while the sauce is at its creamiest.

📝 Notes

Creamy, spicy, and deeply comforting, this is the kind of dinner that disappears straight from the skillet. It’s perfect for busy nights when you still want something that feels a little indulgent and special.

🥗 Nutrition

Serving: 420g | Calories: 640kcal | Carbohydrates: 45g | Protein: 38g | Fat: 36g | Saturated Fat: 20g | Polyunsaturated Fat: 3g | Monounsaturated Fat: 10g | Trans Fat: 1g | Cholesterol: 185mg | Sodium: 720mg | Potassium: 820mg | Fiber: 4g | Sugar: 4g | Vitamin A: 2800IU | Vitamin C: 48mg | Calcium: 180mg | Iron: 3mg